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Immunité

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Immunofree is a mix of evidence-based herbs from across the globe chosen for their potential immune-boosting, lung health, anti-coagulation and organo protective properties. Some of these herbs are already mandatory in certain lands including China, Madagascar and certain states of India.

Reginmune

Reginmune also called Optimune in Europe. Reginmune is a bioregulator that improves the nutritional and energy state of the body. It potentially boosts immunity.

Le mécanisme d'action est censé:

  • Maintenir les mécanismes naturels qui influencent les processus d'immuno-régulation naturelle; il dynamise les mécanismes naturels impliqués dans la restauration de l'homéostasie.
  • Facilitate the bioregulation of the energy, defense systems that are involved in the imbalances of humoral and cellular immunity.
  • Aider à la régulation naturelle du système immunitaire grâce à une action orchestrée d'un groupe d'acides aminés critiques afin de contribuer au maintien des mécanismes naturels de l'immunité.

Immunofree

Immunofree is a mix of evidence-based herbs from across the globe chosen for their potential immune-boosting, lung health, anti-coagulation and organo protective properties. Some of these herbs are already mandatory in certain lands including China, Madagascar and certain states of India.

Reginmune

Reginmune also called Optimune in Europe. Reginmune is a bioregulator that improves the nutritional and energy state of the body. It potentially boosts immunity.

Le mécanisme d'action est censé:

  • Maintenir les mécanismes naturels qui influencent les processus d'immuno-régulation naturelle; il dynamise les mécanismes naturels impliqués dans la restauration de l'homéostasie.
  • Facilitate the bioregulation of the energy, defense systems that are involved in the imbalances of humoral and cellular immunity.
  • Aider à la régulation naturelle du système immunitaire grâce à une action orchestrée d'un groupe d'acides aminés critiques afin de contribuer au maintien des mécanismes naturels de l'immunité.

INGRÉDIENTS

Immunofree:

1. Kalmegh Andrographis panicullata Whole plant 40
2. Bhunimbha Phylanthus niruri whole plant 40
3. Yastimadhu Glycirhizza glabra Root 40
4. Tulsi Ocimum sanctum aerial part 30
5. Guduchi Tinospora cordifolia Ghana satwa 40
6. Pushkarmool Inula racemose Root 30
7. Rasna Alpinia galangal Root 20
8. Draksha Vitis Vinifera Fruit/seed ext 20
9. Haridra Curcuma longa Rhizome 10
10. Haritaki Terminalia chebula Fruit 20
11. Kumari Aloe barbandensis Leaf 20
12. Shilajit- Asphaltum Mineral 20
13. Jasad Bhasma Oxide of zinc Powder 20
14. Pippali Piper longum fruit 5
15. Damanaka/Damar Artemisia nilagirica 40

Reginmune

Each capsule contains:

  • Group I -Phytotheraputic Plant Extracts: Echinacea extract (Echinacea purpurea, 4.0% total polyphenols) 80mg, Aloe vera80 mg, Cat’s Claw extract (Uncariatomentosa, bark, more than 3.0% alkaloids) 80 mg.
  • Group II- Amino acids: L- glutamine 140mg, L-arginine 80 mg, L-lysine HCl 40 mg, L- Isoleucine 20 mg.
  • Group III- Vitamins and minerals: Magnesium gluconate (5.86 %magnesium) 40 mg, Copper gluconate (14.44% copper) 3.5mg, Zinc gluconate(14.35% zinc) 25 mg.
  • Groupe IV - Biopolymère dans la matrice cellulaire: Hyaluronate de sodium 7.5 mg.

RECHERCHE

Immunofree blends a wide variety of phytochemicals, such as alkaloids, polyphenols, flavonoids, saponins, terpenoids, lignans, Xantones etc. These herbs have specifically been chosen based on research done in 2020. We use highly-concentrated full-spectrum extracts of these herbs in Immunofree.

Studies done on individual ingredients have been conducted in the following set-ups:

01 In Vivo study (in the body)

02 In Vitro study (on cells in a lab)

03 In Silica research (Computer modelling of plant DNA vs virus RNA)

Disclaimer: This peer-reviewed and published research has most probably not been studied or approved by the FDA in your country as a treatment or cure. Hence no disease claims can be made and you are welcome to take the natural ingredients for (immunity, lung health, cardiovascular health, etc)

Andrographis/ Kalmegh is the king of bitters. Various studies suggest it dissolves viral envelopes and may help the body get rid of RNA viruses. It is known as chuān xīn lián in chinese medicine and has been mandated in China since février 18 2020.

Kalmegh – Andrographis Paniculata

Studies suggest that Andrographis Paniculata has potent immune boosting and antiviral properties.

Review articles on New Line Phytochemicals 

A paniculata ethanol extract inhibited the SRV virus titer, and it was not toxic to the A459 cell line. Furthermore, low concentration (1 μg/mL) of a paniculata extract could stimulated lymphocyte cell proliferation about 38% compared to the control lymphocyte cell without any treatment.

Supporting research articles for Paniculata

Andrographolide as a potential inhibitor: an in silico approach

Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide

Computational investigation on Andrographis paniculata phytochemicals to evaluate their potency 

For more latest studies please click here.

https://scholar.google.com/scholar?hl=en&as_sdt=0,5&q=%22andrographis+paniculata%22++immune&scisbd=1

Bhumyamalaki- Phyllanthus niruri is popularly known for its Hepato-protective properties. You will find this herb in numerous traditionally used medicines in order to support the liver and boost immunity. The herb may have the ability to inhibit and also destroy viral envelopes.

Bhumyamalaki – Phyllanthus Niruri

Phyllantus is one of the top ranked phytochemicals screened against receptor binding site with their respective structures, docking score, binding affinity and interacting residues. Phyllanthus has been widely used in Ayurveda (traditional Indian medicine) and its biological properties have been studied for  antiviral activity.

Supporting research articles for Bhumyamalaki- Phyllanthus niruri

Structural basis of discovery from medicinal plants

Relevance of Fast Track Integrative Approaches

For more latest studies please click here.

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0,5&q=phyllanthus+niruri+immune

Yastimadhu- Glycirhizza Glabra –Licorice is traditionally known as an Elixir for the lungs. It is believed to have properties to liquefy phlegm and enable easy expectoration and clear airways. Liquorice root, or ‘radix glycyrrhizae’ , is one of the 50 fundamental herbs used in traditional Chinese medicine, where it has the name gancao. Yastimadhu tops the list of Jivaniya Mahakashaya which means it is believed to be  a nutrient as well as rejuvenating remedy.  It is a natural tonic for general debility, chronic fatigue, alkalization and physical exhaustion.

Yastimadhu – Glycirhizza Glabra

Glycyrrhiza glabra plant potentially showed antiviral activities

Research studies conducted to test Glycyrrhiza glabra plant:

Review of antiviral effects of Glycyrrhiza glabra L. and its active component, glycyrrhizin presented a review of the antiviral activity of Glycyrrhiza glabra.

Scope of Glycyrrhiza glabra (Yashtimadhu) as an Antiviral agent: A Review reviewed the antiviral activity of Glycyrrhiza glabra plant.

Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin presented a review of the antiviral and antimicrobial activities of Glycyrrhiza glabra. The authors described the presence of more than 300 flavonoids and 20 triterpenoids in this plant.

Supporting research articles for Glycyrrhiza glabra plant:

Immunomodulatory Herbs of Ayurveda: A review article

Epidemiology, Treatment and Microbiological Surveillance 

In Silico Molecular Docking Studies of Medicinal Arabic Plant-Based Bioactive Compounds 

For more latest studies please click here.

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=%22glycyrrhiza+glabra%22+virus+&btnG=

Tulsi – Ocimum sanctum (Queen of herbs)

Tulsi is a sacred plant in Hindu mythology also known as Vishnu Priya. The plant also known as apet- rakshasi and bhutagni may be related to its properties to ward-off all evil.

Tulsi – Ocimum sanctum

Tulsi has been well documented for its therapeutic potentials and described as Dashemani Shwasaharni (antiasthmatic) and antikaphic drugs (Kaphaghna). Tulsi is traditionally used in fever, bronchitis, arthritis, convulsions etc.

Supporting research articles for Tulsi:

Ayurveda’s Holistic Lifestyle Approach for immunity: Possible Role of Tulsi

Evaluation of traditional ayurvedic preparation using molecular docking approach

Ayurveda Practitioners Consensus to Develop Strategies for immunity

Exploring alternative medicine options for immunity- A systematic scoping review

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Ocimum+sanctum+immune&btnG=

Guduchi – Tinospora cordifolia- Giloy, Amritha

It is called Amrita in Sanskrit, meaning which never dies. The term signifies longevity and immortality.

Guduchi

Guduchi is widely used plant in folk and Ayurvedic systems of medicine is well known for its immunomodulatory activity. Following is a study that suggests the benefits of Guduchi plant: Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi

Supporting research articles for Guduchi:

Indian traditional Ayurvedic treatment regime for immunity

Exploring alternative medicine options for immunity in 2020- A systematic scoping review

Deploying Biomolecules for immunity

Immunity prospective chemical drug therapeutics

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Tinospora+cordifolia+immune&btnG=

Pushkarmool-Inula racemose

Pushkarmool is one of the reputed medicinal plants used in the traditional system of medicine (Ayurveda) for its potential benefits in respiratory and cardiovascular diseases.

Supporting research for Pushkarmool-Inula racemose

Following is the study that attempts to validate the benefits of Pushkarmool:

An Experimental Evaluation of Anti-Asthmatic Potentialitis of Inula racemosa (Puskar Mul)

Nature to Nurture- Identifying Phytochemicals from Indian Medicinal Plants as Prophylactic Medicine by Rational Screening to be Potent 

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Inula+racemosa+root+&btnG=

Rasna-Alpinia Sugandhimool (aromatic roots) – Sugandhimool

Studies suggest Natural Compounds in Alpinia officinarum are Potent Protease Inhibitors.

Some of these studies are:

Revealing the Potency of Citrus and Galangal Constituents 

Natural Product Compounds in Alpinia officinarum and Ginger are Potent  Protease Inhibitors

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Alpinia+galangal+Root+&btnG=

Draksha – Vitis Vinefera

Research suggests Drakha to be beneficial in coagulatory disorder and also help in improving circulation. The anticoagulant effect of polyphenols-rich extracts from black choke berry and grape seeds.

Draksha

The Ministry of AYUSH recommended the use of a decoction of the mixture of Ocimum tenuiorum, Cinnamomum verum, Piper nigrum, Zingiber ocinale, and Vitis vinifera as a preventive measure to boost immunity.

Following researches support the same:

Network pharmacology of AYUSH recommended immune-boosting medicinal plants 

Anticoagulant effect of polyphenols-rich extracts from black chokeberry and grape seeds

Rasayana as Orac Connotation – An Intercessional Health Promotion in 2020

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Vitis+Vinifera+immune&btnG=

Haridra – Curcuma longa

Studies suggest curcumin extracts derived from Turmeric is found to be a strong immune modulator. Curcumin is also considered as a potential immune booster.

Following studies support the claim:

Virtual screening and repurposing of FDA approved drugs.

Potential effects of curcumin in immunity

Ayurveda Practitioners Consensus to Develop Strategies for immunity

Curcumin as a potential mechanism of pathogenesis

Immunity to Save Humanity: A Study

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Curcuma+longa+virus&btnG=

Haritaki- Terminalia chebula- Abhaya, Patya, Harda

The extract of fruits of T. chebula potentially showed inhibitory effects on viruses.

Supporting research articles for Haritaki:

Ayurvedic immunity: A Proposal

Biological and Pharmacological Properties of Terminalia Chebula Retz. (Haritaki) – An Overview

Immunomodulatory herbs of Ayurveda: A review article

Ayurvedic practitioners consensus to develop strategies for immunity

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Terminalia+chebula+immune&btnG=

Kumari- Aloe vera- Gritkumari, Kanyasara, Surasa

Kumari is traditionally used as for liver support and inflammation. Following studies attempt to show its benefits for boosting immunity:

Aloe vera (L.) BurM. F. as a Potential immune booster: A Mini-review of Its Antiviral Activity

Suppression of Host Gene Expression by nsp1 Proteins of Group 2 

Identification of potential inhibitors of protease from Aloevera compounds: A Molecular docking study

A two-pronged strategy to suppress host protein synthesis 

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Aloe+barbandensis+immune&btnG=

Shilajit – Asphaltum

Shilajit, a multi-component natural mineral substance, is known for its potential antioxidant activity, immune response, and disease resistance

Shilajit – Asphaltum

Research suggests that Shilajit potentially and significantly increases Phagocytic activity, Respiratory burst(RB) activity and glutathione peroxidase activity.

Supporting research articles for Shilajit – Asphaltum

Effect of Shilajit enriched diet on immunity, antioxidants, and disease resistance in Macrobrachium rosenbergii (de Man) against AeroMonas hydrophila

Immunity Recommendations of the Hungarian Integrative Medicine Association

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Asphaltum+immune&btnG=

Jasad Bhama – Zinc oxide

Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response.

Jasad Bhama – Zinc oxide

In vitro experiments demonstrate that Zn2+ possesses antiviral activity.

Supporting research articles for Jasad Bhama – Zinc Oxide

Therapeutic Application of Zinc in Opportunistic Infections

Zinc and respiratory tract infections: Perspectives (Review)

Inactivation efficiency on a compound disinfecting nanoemulsion

Immunity: What can we do to Minimize risks

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=zinc+immune&btnG=

Pippali- Piper longum

Commonly known as Pippali or Long pepper which contain piperine, piplartine, pellitorine, caryophyllene etc. as major chemical constituents.

Pippali- Piper longum

The benefits of Pippali have been claimed in various studies. Two recent ones being:

Food as Medicine: a possible preventive Measure 

Immunomodulatory Herbs of Ayurveda: A Review Article

Supporting research articles for Pippali- Piper longum

Epidemiology, Treatment and Microbiological Surveillance 

Ayurveda practitioners consensus to develop strategies for immunity

Exploring alternative Medicine options for immunity- A systematic scoping review

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Piper+longum+immune&btnG=

Artemesia annua

This plant is extensively used in Africa and China and is known for antimalarial properties

Artemisia shows ‘promise’, say researchers

Aromatic Herbs, Medicinal Plant- Derived Essential Oils, and Phytochemical Extracts as Potential Therapies: Future Perspectives

Artemisia annua to be tested 

Discuss about the application of Artemisia annua 

https://scholar.google.com/scholar?hl=en&scisbd=1&as_sdt=0%2C5&q=Artemisia+nilagirica+immune&btnG=

Core Immunity Kit
Core Immunity Kit

$39.00

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L'approche de Biogetica

Guérir l'être entier

Biogetica has a unique and comprehensive Holographic model of healing which synthesizes all prevalent medicine systems to simultaneously ease physical, energetic, mental and emotional layers of your being. Our full spectrum approach works across the entire physical, energetic and informational spectrum of life. Totality is our Modality and we are always open to any tradition or treatment that will benefit you.

Every thought, emotion, vibration or action leads to a series of chemical changes in the body. All ailments are a result of disharmony in the life force. Biogetica recognizes this and balances the ENTIRE BEING, bringing mind, body and soul into harmony, for lasting results. Treating an ailment on molecular level alone, seldom has a lasting effect as the untreated social, emotional, mental, spiritual and energetic patterns will cause the ailment to manifest once again on a physical plane.

Holistic healing is necessary for lasting relief. Biogetica, therefore, uses Resonance Homeopathy to harmonize the entire being; flower essences to attune the mind; Ayurvedic, Amazonian, Tibetan and Chinese herbs to balance the energetic and the physiological manifestation of the five elements; and nutraceuticals to coordinate cellular nutrition. Our approach works across the spectrum of life to balance matter and energy whilst using archetypes of the undying spirit to remind the entropic physical body of its optimal functions. Each human is a child of immortality pre-programmed to perform a billion functions with a mind boggling precision that most science cannot comprehend. Each of our kits potentially provides specific nutrition needed for a particular function, the herbs in these kits balance the terrain of the body to make it conducive to that function and the vibrational therapies potentially help bring balance.

Recherchez des solutions naturelles

Nos corps sont faits et soutenus par la nature et ne peuvent donc être guéris que par la nature à long terme. Les produits chimiques sont souvent nécessaires pour un changement immédiat dans une situation aiguë mais tendent à faire plus de mal au corps qu'à long terme. Par conséquent, les médecins de Biogetica se consacrent à fournir des solutions naturelles qui sont soutenues par des preuves et une utilisation antérieure. Pour nous, l'argument est assez évident: on utilisait le bois pour fixer un bureau en bois ou en métal pour réparer une voiture en métal, alors pourquoi utiliser des produits chimiques pour fixer un corps fait de la nature?

Nature has blessed the Earth with natural medicines and healing mechanisms. It would be wise not to ignore them. The intelligence of nature is much greater than that of man. Unfortunately, man still focuses on chemical medicines, as they can be patented and sold for huge profits. Allopathic attempts to treat chronic ailments by interfering directly with the chemical processes using man-made substances, has essentially been a failure. We claim to be cracking the gene code, but we still can’t cure a cold with man-made substances!!! Homeopathic and Naturopathic methods are never studied and verified by governing bodies, as there is no one who will spend millions obtaining an approval on herbs, knowing that they cannot be patented and sold exclusively by them.

Faire appel aux forces d'équilibrage inhérentes à toute nature

La vie ne peut pas être recréée avec des interactions chimiques et il y a beaucoup plus à la vie que les interactions moléculaires. Nos corps sont les pharmacies les plus avancées sur la planète et des millions de fonctions se produisent chaque minute avec une précision étonnante. Les thérapies Biogetica sont conçues pour faire appel aux forces d'équilibre apparentes dans toute la nature en rappelant et en stimulant le corps vers une certaine fonction. Les nutraceutiques dans nos kits fournissent une nutrition spécifique pour une fonction, les herbes de nos kits équilibrent le terrain du corps pour qu'il puisse remplir cette fonction et les homéopathies par résonance sont conçues pour rappeler au corps d'être en résonance avec cette fonction même .

De médicaments à la méditation

La bonne santé et la liberté impliquent chaque aspect de notre être comprenant le régime, le style de vie, l'exercice, les états émotifs, les pensées et les modèles énergiques. Les Dr Biogetica ont donc conçu des protocoles d'alimentation, de nutrition, d'exercice et de méditation spécifiques à diverses situations de la vie. Nous vous encourageons à y participer activement pour de meilleurs résultats.

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Biogetica’s mission is to heal the people of this globe with evidence based natural remedies and thereby once again give nature’s medicines the respect they deserve.

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Related System Support Supplements

Kit

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EU Core Immunity Kit

EU Core Immunity Kit

The EU core immunity boost kit is essential for today. It contains amino acids, herbs and vitamins essential to boosting immunity and lung health. Some of these formulas are now on national advisories given to people by the Indian and Chinese government. Ingredients include : Aerovent, Soluvin & Reginmune

BIO 88

Ingrédients:   Coxsackie D30, D60, D200; Diphterinum D30, D60, D200; Epstein Barr D30, D60, D200; Eugenia Caryophyllata D3; Euphrasia officinalis D5; L'herpès simplex D30, D60, D200; L'herpès zoster D30, D60, D200; Influenzium D30, D60, D200; Mononucléose D30, D60, D200; Morbillinum D30, D60, D200; Poliomyélite D30, D60, D200; V-grippe D30, D60, D200; L'éthanol; Aqua Purificata.

Dosage: Pour les adultes, administrer 10 gouttes, 3 fois par jour

BIO 88 ne peut pas être expédié en Californie.

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Les références

MEDICAL DISCLAIMER

Tous nos produits sont fabriqués dans des laboratoires certifiés GMP conformes à la FDA en Allemagne, en Suisse, aux États-Unis, en Inde et en Espagne. Ils sont dûment enregistrés auprès de la FDA comme suppléments diététiques, atténuations homéopathiques ou herbes ayurvédiques. Un soin extrême est apporté pour assurer une qualité et une pureté optimales. Biogetica est un site web visité à travers le monde. Certains pays considèrent l'Ayurveda, la MTC, les Suppléments, la Bioénergétique et l'Homéopathie comme des médicaments, tandis que d'autres ne le font pas. Afin de se conformer à diverses normes de la FDA de nombreuses nations, nous disons:

Ayurveda & Homeopathy may or may not qualify as medicine in your home jurisdiction. The complementary advice of our practitioners who are considered Homeopathic and Ayurvedic Doctors in some jurisdictions does not replace the medical advice given by your primary care physician. Biogetica’s Homeopathic products may be used for treatment of self limiting over the counter ailments in USA, India & Europe that support Homeopathy for OTC use. Biogetica’s Herbal remedies from the Ayurvedic, Chinese and other traditions may only be used to balance the 5 elements and rejuvenate organ systems in countries where Herbs, Ayurveda and TCM are not considered medicine. Biogetica’s ground breaking supplements may only be used to support the ideal structure and function of the various systems in the Human Body.

Les informations fournies sur ce site n'ont pas été évaluées par la Food and Drug Administration. Nos produits ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir une maladie.

* This peer reviewed and published research has most probably not been studied or approved by the FDA in your country as a treatment or cure. Hence no disease claims can be made and you are welcome to take the natural ingredients for (immunity, lung health, cardiovascular health, etc). Homeopathy is medicine in USA but only for OTC issues. Ayurveda is medicine only in India and TCM is medicine only in China. Switzerland supports insurance payments for Homeopathy.

Selon l'énoncé de politique d'application de FTC sur des réclamations de vente au détail pour des médicaments homéopathiques de vente libre que n'importe qui vendant l'homéopathie doit indiquer.

Il n'y a pas suffisamment de preuves scientifiques que l'homéopathie fonctionne, et

The product’s claims are based only on theories of homeopathy from the 1700s that are not accepted by most modern medical experts.

** Nos remèdes ont été traditionnellement utilisés en Ayurveda et Homéopathie depuis des siècles. Chaque remède a une quantité variable de recherche moderne derrière elle. Nous, en respectant la loi, ne prétendons pas à un remède miracle ou à des résultats permanents. Les résultats individuels peuvent varier d'un individu à l'autre.

*** Essayez nos produits maintenant! Notre garantie 100% de remboursement inconditionnel est valide pour 90 jours.

† All Homeopathic products are made in accordance with the Homeopathic Pharmacopoeia of the United States, a document which has been published for over 100 years and which is recognized as an “official compendium” by Sections 501(b) and 502(e)(3) of the Federal Food, Drug, and Cosmetic Act, 21 U.S.C. 351(b) and 352(e)(3) (“FD&C Act”).” These indications are based solely on traditional homeopathic use. They have not been evaluated by the Food & Drug Administration.

†† These testimonials are unsolicited and unedited except for the name of the sender. They contain the senders’ initials or first name only for purposes of privacy. These are actual emails from many we were able to help over the years. Testimonials represent a cross section of the range of outcomes that appear to be typical with these products. Your results may vary. We do however stand by our products and will refund you completely if our products don’t meet your expectations.

What we do is simply point you and your Doctors to independent research from all sources that we know of, on the ingredients or entire formulation of our natural products, which are Herbal, Ayurvedic, Bioenergetic, Homeopathic and Complementary in nature. We invite you to read these studies on our clinical trials page or on scholar.google.com. Results may vary from person to person as is depicted in the wide range of results seen in the clinical trials.

 

 

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